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Home > Dr.Keerthi.T.R.

Dr.Keerthi.T.R.

  Professor in Biotechnology
School of Biosciences,Mahatma Gandhi
University
PD.Hills(PO),Kottayam,Kerala,India-686 560
Ph:9497655293,Office: +91-481-2731035.
Email:keerthisureshbabu@gmail.com.,keerthisur
eshbabu@yahoo.co.in.,keerthithalakattilraghava
n@gmail.com.

Director, School of Biosciences, Mahatma Gandhi University.

Qualification

  • M.Sc., Ph.D.

Area of specialization

  • Biotechnology

Research area

  • Probiotics,Prebiotics &Microbiome Research
    and Bioprospecting of MarineMicrobes

Education

                1995 – 2001          Ph. D.,Biotechnology Department of Biotechnology Cochin University of Science and Technology Cochin, Kerala, India
                1991 – 1993          M.Sc., Microbiology School of Biosciences
Mahatma Gandhi University
Kottayam
                1987 – 1990               B.Sc., Botany Vimala College, Trichur,
Calicut University, Kerala

Professional Experience

  • Research experience: Twenty years
  • Teaching experience: Fourteen years (PG level-Fourteen years, UG level three years)
   Sl.
No.		            Institution Place        Position     From (Date)        To (date)
    1 School of Biosciences, Mahatma Gandhi
University, Kottayam		        Director      17-08-2015        Continue
    2 School of Biosciences, Mahatma Gandhi
University, Kottayam		        Professor      24-05-2012        Till date
    3 School of Biosciences, Mahatma Gandhi
University, Kottayam		        Associate
Professor		     23-05-2009       23-05-2012
    4 St. Mary’s College, Trissur        Lecturer
(Contract Bases)		     06-06-2005       22-05-2006
    5 Sanjivani College of Paramedical and
Applied Sciences, Pallimukku, Cochin.
(Under Panjab Technichal University)		        Lecturer     02-09-2002       05-09-2004
    6 Kerala Agriculture University,
Mannuthi, Kerala		        Research
Associate		     10-07-2000       31-08-2002

Research

Ph.D. Topic: Studies on L-Glutaminase production by marine Pseudomonas sp.

The areas of research include optimization and characterization of medically and industrially
important enzyme L-Glutaminase from marine Pseudomonas sp. Anti-neoplastic activity of
this enzyme was proved in animal models.

Research Area

Probiotics

Probiotics are commonly defined as mono or mixed cultures of live microbes that when
applied to an animal or human, posses a beneficial effect on the health of host possibly by
improving the balance of the indigenous microflora. The predominant species used as
probioticagents belongs to the group of LAB.Recent scientific investigations have supported
role for probiotics as a part of healthy diet for humansand may be an avenue to provide a
safe, cost effective barrier against microbial infection. In order to satisfy the increasing
request of the market and to obtain new functional products containingprobiotic cultures with
more active and better probiotic characteristics, the isolation andcharacterization of new
strains is desirable, mainly in developing countries.Our research group focus to isolate &
charecterise potential wild strains of probiotics from different natural sources and based on
their probiotic potency further study has conducted for to develop a product oriented way
either therapeutic /neutraceutical applications or formulation of functional animal/aquaculture feed.

Prebiotics

Prebiotic are special form of dietary fiber that beneficially nourishes the good
bacteria/probiotics already in the large bowel or colon. The body itself does not digest these
plant fibers; instead, the fibers act as a fertilizer to promote the growth of many of the good
bacteria in the gut. These, in turn, provide many digestive and general health benefits.
Prebiotic fibers contain inulin lactulose and oligofructose. Sources of prebiotic fibre are
Acacia gum, Chicory root, Onion, raw banana, oats etc.Our research group try to develop
synbiotic(combination of prebiotic & probiotic)based functional food /feed for better
fuctionability.

Microbiome

Research has shown that the microbiome is linked to natural immunity, metabolism,
behavioural traits, and broadly speaking, plays an instrumental role in health and disease.
Developments in the field of metagenomics have allowed researchers to explore the diverse
microbiota in the human body. With large-scale collaborative projects underway and
sequencing data placed in the public domain, there is a rich source of information for
researchers and companies looking for opportunities in this exciting field. Increasingly, there
are indications that the human microbiome is key to curative and preventative medicine, so
efforts are being focused on expanding investment opportunities, performing more clinical
trials and spurring innovative research in this area.Understanding the importance of
microbiome study &also our search of natural host specific/organ specific probiotic we also
extend our resaerch work to microbiome analysis of different organisms and even different
site/organs such as Gut,Skin,Feces ,breast etc.

Bioprospecting of Marine Microbe

The marine environment remains as the vast treasure of unexplored compounds with
bioactivity. The diversity in chemical structure and bioactivity of these novel compounds
emphasize the extreme conditions of temperature, salinity, pressure and the competition
which they have to adapt. A large portion of the presently utilized natural product derived
compounds has been formulated from terrestrial sources. Nonetheless, mining marine
diversified specimens will surely help for the disclosure of novel drugs too. Recent researc
point out that the natural products obtained from marine sources are chemically more
diversified than terrestrial natural products. Various organically dynamic compounds
anticancer, antimicrobial, antifouling, Etc. have been separated from marine sources. Some of
these bioactive particles have been as of now chosen for treating different illnesses and a
large number of them are under clinical examinations.Understanding the unexplore area of
bioresource our research area also extended to bioprospecting of marine organisms especially
marine microbes,sponges & sponge associated symbiotic microbes..

Projects undertaken

Completed.
Principal investigator

UGC Major Project sanctioned dated 13/01/2010 and F. No. 37-264\2009 (SR) 09.
Period :3yrs 2009-2013, Amount:10,77000
Title: “Production, Purification and Characterization of antagonistic principles of Potential
Aquaculture probiotics”.

Co- investigator

KSCSTE Major project sanctioned dated 24-12-2008 Order No(T)298/SRS/2008/CSTE.
Period: 3yrs- 2009-2011,Amount: 10,92,300/-
Title: “Protective effect of Elephantopus scaber Linn. A traditional medicinal plant on hepatic fibrosis
and hepatocellular carcinoma”.

Ongoing research projects

DST-SERB, New Delhi.Major project (SB/EMEQ-137/2013) DST-SERB, New Delhi.)
Period: 4yrs-2013-2017,Amount: 30,36,400/-
Title: ‘Exploration of honey bee gut microbiota for industrial and therapeutic applications’

Sanctioned and awaiting fund release.

Title:Health promoting properties of potential probiotic strains isolated from gut microflora’. ICMR,
New Delhi, (Collobarative with Dr. Sabu Thomas Scientist E11 as Co-PI,Rajiv Gandhi Centre for
Biotechnology).

Submitted

Indo-Iran Bilateral Inernational collaborative proposal –School of Biosciences Mahatma Gandhi
University and Human and Animal Probiotic Research Department Razi Vaccine and Serum research
Institute,Iran

DST, New Delhi. Title: Project title: Anti-infectious property of potential probiotic strains of human
origin against Vibrio cholera (Collobarative with Dr. Sabu Thomas Scientist E11 as PI, Rajiv
Gandhi Centre for Biotechnology).

Honors

  • 2017:Travel grant for invited speaker at “16th World Congress onNutrition and Food Chemistry”Zurich, Switzerland September 18-20, 2017.UGC
  • 2014: Travel grant for invited participation at 4th Annual International Conference on Advances in
    Biotechnology (BioTech 2014) Dubai, BITS Pilani Campus 10-11th March 2014.UGC
  • 2011: Travel grant for invited participation at “.Asian Congress on Biotechnology, “ACB 2011” held
    during May 11-15, Shanghai, China.UGC

Ph. D. Awarded under guidance -4

    Sl
No		                     Title         Name of Student        Year
    1 In vitro studies on the probiotic potential of bacterial
strains isolated from Poecilia reticulata (Guppy) and
characterization of their antagonistic principles’		      Aparna Balakrishna        2012
    2 An Experimental study on Probiotic Effect of Spore
formers		         Anu P. Sebastian        2013
    3 Synthesis and characterization of marine yeast
polysaccharides		       Savitha K Koilery        2013
    4 The probiotic and health promoting capabilities of
Enterococcus faecium isolated from
infant feces		       Anjali Anne Jacob        2014

Ongoing Ph. D programme under supervision:7

   Sl no            Name                            Title         Position
     1 Glyindya
Bhagyalakshmi		 Biotechnological Application of
Probiotics in Aquaculture		 Research fellow
     2 Smt.Resmi.S.S Biophysical characterization of
bacteriocin produced by
lactic acid bacteria		 Faculty,School of
Biosciences
     3 Athira Krishnan
K.A		 Screening, biological evaluation &
characterization of
bioactive molecules from marine
sponges &its
symbiotic bacteria as potential
anticancer drug		 DBT INSPIRE
FELLOW
     4 Honey
Chandran C.		 Beneficial and health promoting effect
of lactic acid
bacteria from honey bee gut		 Project fellow
DST-SERB
     5 Nithin T.U Production, purification and
biophysical
characterization of anti cancer
bioactive compounds
from selected marine microbes		 Research Fellow
UGC-NET
     6 Sudha V
Gopinath		 Comparative study of methods for
analysis of glycosyllization of
indigenously developed therapeutic
monoclonal antibodies.		 Scientist,National
Institute of
Biologicals,(Ministry
of health & family
welfare,Gov of
India,New Delhi.)
     7 Rakhi Narayanan Therapeutic application of
Bifidobacterium .		 KSCESTE-JRF

 

M. Phil. Dissertations supervised                        7
M.Sc. Dissertations supervised                       11

Invited Lectures

1.“Current Status of Functional Food/Nutraceuticals:What Obstruct R and D in Probiotics in
India”.International Seminar on Globalisation and India’s Innovation System:A ‘Creative
Destruction’? “GIIS 2017”Februvary 4-6 2017.Kottayam,Kerala,India.

2.“Probiotic Fermentation Enhances the MultiFunctionability of Aquafeed”.International Conference
on Science & Technology for National Development 25& 26th October,2016organized by KUFOS in
association with indian Science Congress Association-Cochin Chapter.

3.“Intervention of probiotic Lactobacillus plantarum from Honey bee gut against Life style
Diseases.”International Conference on Nutraceuticals & chronic Diseases september 9-
11,2016,Cochin,Kerala organized by Society of translational Cancer research & indian Instituteof
technology(IIT) Guwahati,Assam,India.

4.“Role of Probiotics in Functional Food/Neutraceuticals.””UGC Sponsored National Seminar on
“Food Safety in India-Current Issues and Career Prospects-National Biotechnology Seminar-2015”,8-
9 October 2015,organized by Department of Biotechnology,St. Peters College ,Kolenchery

5.“Role of Lactobacilli in gut microbiota”. ZEITGEIST, (2014). Microbial conference and Cultural
Fest,25th June 2014, By Association of Medical microbiology students, University College of
Medical Education, Gandhinagar, Kottayam, Kerala.

6.“Co synthesis of Citric Acid during Polysaccharide Production by a Marine Yeast Meyerozyma
gullermondii MBTU-MYW1 (JN128648)” 4th Annual International Conference onAdvances in
Biotechnology (BioTech 2014)Dubai,,BITS Pilani Campus 10-11th March 2014

7.“Probiotic as health promoting neutraceutical and therapeutic agent.” UGC sponsored National
Seminar cum Workshop on Techniques in Biosciences, February 18th to 19th 2014, Department of
Botany, KKTM Govt. College. Kodungallur.

8.“Immunomodulatory effect of probiotic strain Bacillus subtilis MBTU PBBMI spores in Balb/C
Mice”. TSB International Forum-2013 BITEC Bang Na, Bangkok, Thiland, August 28-30, 2013.

9.“Characterization of Enterococcus faceium infant gut flora for application in functional food”.
International Biotechnology Symposium, “IBS 2012”, September 16–21, 2012, Daegu, Korea.

Chair – Scientific session

1.International Conference on research methodology and scientific writing, School of Behavioural
Sciences , Mahatma Gandhi University, Kottayam, Kerala-December 21-22nd 2013

2.International Biotechnology Symposium, “IBS 2012”, September 16–21, 2012, Daegu, Korea.

List of Publications

Journal Publications/articles

  1. Athira Krishnan K.A. & Keerthi T.R. (2016) Comparative Evaluation of Bioactivities of
    twoMarine Sponges, Zygomycale parishii and Callyspongia diffusa from Southwest Coast of
    India British Journal of Pharmaceutical Research11(1): 1-10, 2016, Article
    no.BJPR.24740ISSN: 2231-2919, NLM ID: 101631759
  2. Honey Chandran C., Meenu Das M. and Dr. Keerthi T. R.(2016) “ Effect of prebiotics
    on synbiotic fermented milk” World journal of pharmacy and pharmaceutical
    sciences,Volume 5, Issue 2, 1557-1566
  3. Honey Chandran C.1, Summaya Jauhara2 and Dr. Keerthi T. R.(2016) “Probiotic
    effect of bacillus coagulans, mbtu-p1f2 from infantfaeces with a known
    probiotic” European journal of biomedical and pharmaceutical sciences Volume 3,
    Issue 3, 298-304.
  4. Athira Krishnan K.A. &Keerthi T.R. (2016) “Analyses of methanol extractsof two
    marine sponges, Spongia officinalis var. ceylonensis and Sigmadocia carnosa from
    Southwest coast of India for their bioactivities” International Journal of Current
    Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 2(2016) pp. 722-734
    Journal homepage: http://www.ijcmas.com
  5. Anu P. Sebastian and Keerthi T.R.,(2015) “Molecular characterization and health
    promoting attributesof MBTU PBBM1 isolated from cow milk” International Journal of
    Current Microbiology and Applied sciences. ISSN: 2319-7706 Volume 4 Number 6
    (2015) pp. 840-845.
  6. Anu P Sebastian, Keerthi. T. R. (2014) Immunomodulatory effect of probiotic strain
    Bacillus subtilis MBTU PBBMI spores in Balb/C Mice.International Journal of
    Engineering and Technical Research (IJETR)ISSN: 2321-0869, Volume-2, Issue-11,
    November 2014.
  7. Anjali Anne Jacob and Keerthi. T. R( 2014); Characterization of antibacterial compound
    produced by the potential probiotic Lactic Acid Bacteria Enterococcus faecium MBTU-P1F1
    isolated from infant feces against typhoid fever pathogens, Nepal Journal of Epidemiology;
    2014, Vol. 4 Issue 2, p6. SOURCE TYPE. Academic Journal. DOC. TYPE. Abstract.
  8. Raghavan K.T., Honey Chandran and Anjali Anne Jacob (2013). Honey Bee gut flora as a
    source of LAB (Lactic Acid Bacteria) with probiotic capabilities. The Journal of food
    Technology. Photon 105 (124-134). ISJN: 3852-1875.
  9. Raghavan K.T., Anjali Anne Jacob and Honey Chandran (2013). Probiotic and health
    promoting capabilities of Enterococcus faecium from infant gut flora for application in
    nutraceuticals. The Journal of food Technology. Photon 105 (115-125) ISJN: 3852-1875..
  10. Anu P Sebastian and T. R. Keerthi, (2012). Adhesion and cell surface properties of wild
    species of sporeformers against enteric pathogens. Asia Pacific Journal of tropical
    medicine. (ISSN 1995-7645)..
  11. Savitha K. Koilery and T. R. Keerthi, (2012). A study of isolation and biodiversity of
    marine yeast in Arabian Sea. International Journal of Pharma and Biosciences.
    ISSN0975-6299.
  12. Aparna Balakrishna and T. R. Keerthi,(2012). Screening of potential aquatic probiotics
    from the major microflora of guppies (Poecilia reticulata) Front. Chem. Sci. Eng. DOI
    10.1007/s11705-012-1283-4.
  13. Savitha K. Koilery and T. R. Keerthi, (2012). A study of morphological alterations of
    Meyerozyma guilliermondii (JN128648) cells during mannan synthesis. Res. J. Pharm. Biol.
    Chem. Sci. (ISSN: 0975-8585). 3(2): 563-569.
  14. Anu P. Sebastian and Keerthi T. R.(2012). Probiotic effect of wild species of Bacillus
    spore formers and its effect on enteric pathogens. International Journal of Pharma and Bio
    Sciences, ISSN 0975-6299. 3(1): 327-334.
  15. Anu P. Sebastian, Jacob Anjali Anne and T. R. Keerthi, (2012). Probiotic potential of
    bacterial species from natural sources. “The Global Voice of Probiotics”, International
    Probiotics Association. International probiotics.org/news/upload/pdf/33.pdf.
  16. T. R. Keerthi., Anu P. Sebastian (2012) Invitro adhesion and invivo colonization are
    desired probiotic characters of MBTU PBBM1 Bacillus subtilis isolated from milk”J
    Biotechnol Biomater 2012, 2:6 http://dx.doi.org/10.4172/2155-952X.S1.012
  17. Savitha K. Koileryand T.R. Keerthi (2012)”Hydrolytic enzyme production by marine
    yeasts isolated from Arabian Sea “J Biotechnol Biomater 2012, 2:6
    http://dx.doi.org/10.4172/2155-952X.S1.020
  18. Aparna Balakrishna and T. R. Keerthi, (2011). Characterization of siderophore produced
    by the gut microflora of Poecilia reticulata for potential use as probiotic in aquaculture. J.
    Plant. Pathol. Microbiol. 2011/ Volume S1: 013(2011) /Special Issue 2011, doi:
    10.4172/2157-7471.1000001.
  19. Jacob Anjali Ann, R. J. Praseeja and T. R. Keerthi, (2010). Evaluation of Probiotic
    potential of Lactic acid bacteria isolated from Infant feces and the study of its effect on the
    Enteric Fever pathogens Salmonella typhi and Salmonella paratyphi A. Int. J. Chem. Sci.
    8(5), 376-387.
  20. A. Sabu, T. R. Keerthi, S. Rajeev Kumar, M. Chandrasekharan. (2000). L-glutaminase
    production by marine Beauveria sp. Under solid state fermentation. Process Biochemistry,
    35(7) 705-710.
  21. Keerthi T. R., P.V. Suresh, A. Sabu, S. Rajeev Kumar and M. Chandrasekharan. (1999).
    Extracellular production of L-Glutaminase by marine Beauveria bassiana BTMF S10
    isolated from marine sediment. World Journal of Microbiology and Biotechnology,15:
    751-752.

Proceedings

International

  1. Keerthi Thalakattil Raghavan 1 *,Honey Chandran C 1 , JeenaSusan 1 (2017) Lactic Acid
    Bacteria is an evergreen beckoning of probiotic:A special emphasis onLactobacillus
    plantarum”. 16th World Congress onNutrition and Food Chemistry”Zurich, Switzerland
    September 18-20, 2017(invited lecture-Abstract only).
  2.  “Current Status of Functional Food/Nutraceuticals:What Obstruct R and D in Probiotics in
    India”.International Seminar on Globalisation and India’s Innovation System:A ‘Creative
    Destruction’? “GIIS 2017”Februvary 4-6 2017.Kottayam,Kerala,India(invited lecture)
  3. Glindya Bhagya Lakshmi,. and Keerthi T. R. (2016). “Probiotics for organic
    aquafarming”International seminar on emerging trends in organic farming and sestainable
    agriculture “IUCOFSA 2016”held during 29-31st December2016 Mahatma Gandhi
    University,Kottayam,Kerala. Pp-77.Abstract only.
  4.  Keerthi T. R. (2016). “ “Probiotic Fermentation Enhances the Multi Functionability of
    Aquafeed”.International Conference on Science & Technology for National Development
    25& 26th October,2016organized by KUFOS in association with indian Science Congress
    Association-Cochin Chapter Pp(invited lecture)
  5. Athira Krishnan K.A& Keethi T.R(2016) “Anti cancer and antioxidant activities of theorganic
    extracts of the isolate MBTU SOLY1 isolated from the marine sponge ,Spongia
    sp”.International Conference on “NextGen Genomes,Biology,Bioinformatics and
    Technologies (NGBT)”.October 03-05 Cochin.Pp-160 Abstract only.
  6. Honey C.Chandran, Keerthi.T.R (2016). “Intervention of probiotic Lactobacillus plantarum
    from Honey bee gut against Life style Diseases.”International Conference on Nutraceuticals
    & chronic Diseases september 9-11,2016,Cochin,Kerala organized by Society of translational
    Cancer research & indian Instituteof technology(IIT) Guwahati,Assam,India.Pp-49(Abstract
    only)
  7. Glindya Bhagya Lakshmi, Keerthi T.R.(2016) “Standardized method for maintaining viability
    and feed stability in probiotic based fish feed formulation” International conference on
    Towards a Sustainable Blue Economy: Production, Strategies and Policies” organized by
    KUFOS, Panangad, Kochi & Nansen Environmental Research Centre, India during 4-6
    February 2016.Abstract Only.
  8. Keerthi T. R.Amrutha H and Savitha K. Koilery(2014). Co synthesis of Citric Acid during
    Polysaccharide Production by a Marine Yeast Meyerozyma gullermondii MBTU-MYW1
    (JN128648) 4th Annual International Conference on Advances in Biotechnology (BioTech
    2014)Dubai,,BITS Pilani Campus 10-11th March 2014 ISSN:2251-3159
  9. Anu. P. Sebastian and Keerthi T. R.(2013). “Immunomodulatory effect of probiotic strain
    Bacillus subtilis MBTU PBBMI spores in Balb/C Mice”. TSB International Forum-2013
    BITEC Bang Na, Bangkok, Thiland, August 28-30, 2013.Abstract Only
  10. Nithin.T.U;Keerthi.T.R & Linu Mathew (2013). “Bioactive properties of ethyl acetate extract
    fraction of marine Flavobacterium sp isolated fromvizhinjam”.International Conference on
    research methodology and scientific writing, School of Behavioural Sciences , Mahatma
    Gandhi University, Kottayam, Kerala-December 20-22nd 2013.abstract only
  11. Savitha K. Koilery and Keerthi T. R. (2012). “Structural analysis of polysaccharide mannan
    from a marine yeast Meyerozyma guilliermondii (JN128648) using 1H and 13C NMR
    Spectroscopy”. International Conference on Advances in Biological Sciences “ICABS 2012”
    held during 15-17 March 2012, Kannur, Kerala, India. Abstract only
  12. Glindya Bhagya Lakshmi, Anjali Anne Jacob, Anu P. Sebastian, Resmi S.S. and Keerthi T. R.
    (2012). “Health promoting microflora from natural sources”.International Conference on
    Advances in Biological Sciences “ICABS 2012” held during 15-17 March 2012, Kannur,
    Kerala, India. Abstract only

National

  1. Keerthi.T.R Invited lecture “Pobiotics as health promoting nutraceutical and therapeutic
    agent” UGC sponsored National Seminar cum Workshop on Techniques in Biosciences,
    February 18th to 19th 2014, Department of Botany, KKTM Govt. College.
    Kodungallur.Proceedings,Page No.24-28.
  2. K. A. Athira Krishnan, T.R. Keethi, and K. Jayachandran(2014) Screening of bioactivity and
    analysis of chemical constituents of two organic extracts of the marine sponge, Zygomycale
    parishii Proceedings of National Symposium on Emerging Trends in Biotechnology 2014:
    Department of Biotechnology,Cochin University of Science and Technology,Cochin-22
    ISBN-978-93-80095-47-9:40-49
  3. Nithin T. U., Keerthi T.R.,and LinuMathew(2014) Bioprospecting of novel marine bacteria
    Idiomarinaceae MBTU MB2 isolated from coastal region of Thrissur district Proceedings of
    National Symposium on Emerging Trends in Biotechnology 2014: Department of
    Biotechnology,Cochin University of Science and Technology,Cochin-22 ISBN-978-93-
    80095-47-9:60-71
  4. Anu P. Sebastian and Keerthi T.R., (2012).”Adhesion and cell surface properties of wild
    species of Bacillus spore formers against enteric pathogens”. Published in proceedings,
    National Seminar on Life Style and Diseases. January 19-20, 2012. School of Biosciences,
    Mahatma Gandhi University, Kottayam, Kerala. ISBN-978-93-49-416
  5. Anu P. Sebastian and Keerthi T. R., (2011). Adhesion property is an enhanced probiotic
    potential of Bacillus subtilis MBTU_PBBM1 against Enteric pathogens. Published in
    proceedings, National Seminar on Emerging Trends in Biopharmaceuticals, 26-27 August
    2011, St. Mary’s College, Trissur. Page no. 19-21.
  6. Anjali Anne Jacob, Sherin Joy Parapilly and Keerthi T. R., (2011). In vitro probiotic
    characterization of Lactic Acid Bacteria isolated from infant feces with anti microbial action
    towards enteric fever pathogens. Published in proceedings, National Seminar on Emerging
    Trends in Biopharmaceuticals, 26-27, August 2011, St. Mary’s College, Trissur. Page no. 24-
    30.

State

  1. Bincy Jacob, K.A. Athira Krishnan, T.R. Keerthi, K.Jaychandaran(2015). Antagonistic and
    cytotoxic effect of different cellular components of a marine symbiont MBTU-SOB1 from a marine
    sponge, Spongia officinalis var. ceylonensis Proceedings of the 27th Kerala Science Congress,
    Alappuzha. January 27-24, 2015.p.162 Abstract only.
  2. Sumayya Jauhara, Honey Chandran C., Keerthi T.R. (2015). Comparative evaluation of probiotic
    potency of Bacillus coagulans, MBTU-P1F2 from infant faeces with a kniwn probiotic Bacillus
    clausii from Enterogermina. 27th Kerala Science Congress, Alappuzha. January 27-24, 2015. p.164.
    Abstract only
  3. K.A. Athira Krishnan, T.R. Keerthi and K. Jayachandran(2014) Bioactivity and chemical
    composition of two organic extracts prepared from Marine sponge, Spongia officinalis var.
    ceylonensis Proceedings of 26th Kerala Science Congress 28-31, January, 2014, Wayanad,
    Kerala:3242-49
  4. Nithin T.U., T.R. Keerthi, and Linu Mathew (2014) Bioactive properties of ethyl acetate fraction
    of marine bacteria Staphylococcus warneri Proceedings of 26th Kerala Science Congress 28-31,
    January, 2014, Wayanad, Kerala:3261-70

In Seminars/Conferences
International
Oral/Poster Presentations

  1. Keerthi, T. R.,Jacob Anne Anjali,Chandran Honey,Sebastian Anu&Thomas Sabu.(2013).
    “Potential Probiotics from different Natural Sources Having Multifunctional Role” 7thAsian
    Conference on Lactic Acid Bacteria”. September 6-8, 2013, India Habitat Centre, New Delhi, India..
  2. Savitha K. Koilery and Keerthi T. R. (2012). “Anticancer effects of mannans from a marine yeast
    Meyerozyma guilliermondii (JN128648) in MCF7 Human breast cancer cells”. International
    Biotechnology Symposium, “IBS 2012”, September 16 – 21, 2012, Daegu, Korea. Oral presentation.
  3. Anu. P. Sebastian and Keerthi T. R. (2012). “In vitro Adhesion and in vivo colonization are desired
    probiotic characters of MBTU_PBBM1 Bacillus subtilis isolated from milk”. 3rd World Congress on
    Biotechnology, September 13-15, 2012, HICC, Hyderabad, India. Oral Presentation.
  4. Savitha K. Koilery andKeerthi T. R. (2012).“
    Structural analysis of polysaccharide mannan from a
    marine yeast Meyerozyma guilliermondii (JN128648) using 1H and 13C NMR Spectroscopy”.
    International Conference on Advances in Biological Sciences “ICABS 2012” held during 15-17
    March 2012, Kannur, Kerala, India. Poster Presentation.
  5. Glindya Bhagya Lakshmi, Anjali Anne Jacob, Anu P. Sebastian, Resmi S.S. andKeerthi T. R.
    (2012). “Health promoting microflora from natural sources”.International Conference on Advances in
    Biological Sciences “ICABS 2012” held during 15-17 March 2012, Kannur, Kerala, India.Poster
    Presentation.
  6. Anjali Anne Jacob and Keerthi T. R. (2012). “Lactic Acid Bacteria Enterococcus faceium
    MBTU_P1F1 from intestinal commercial flora has antibacterial and essential probiotic properties”.
    International Conference of Regulator Network Architecture in Bacteria, “RNAB 2012”, March 09-2012, Sastra University, in Association with Rajiv Gandhi Center for Biotechnology. Poster presentation.
  7. Anjali Anne Jacob and Keerthi T. R. (2012). “Partial characterization of bacteriocin like substance
    against enteric fever pathogens produces by Enterococcus faceium MBTU_P1F1 from infant gut
    microflora”. XL Dairy Industry Conference, February 2-5 2012, New Delhi. Poster Presentation.
  8. Savitha K. Koilery andKeerthi T. R. (2012). “Hydrolytic enzyme production by marine yeasts
    isolated from Arabian Sea”. 3rd World Congress on Biotechnology, September 13-15, 2012, HICC,
    Hyderabad, India. Poster Presentation.
  9. Savitha. K. Koilery and Keerthi T. R. (2012). “Synthesis and charecterisation of mannan based
    nanomaterial from a marine yeast Meyerozyma guilliermondii”. 5thInternational Conference on
    Sensors,”ASIASENCE-2011” held during oct-21-27, 2011, Jeju, Korea. Oral presentation.
  10. Savitha K. Koilery andKeerthi T. R. (2011). “Identification and characterization of exomannan and
    cell walll mannan from a marine yeast Meyerozyma guilliermondii”. Asian Congress on
    Biotechnology, “ACB 2011” held during May 11-15, Shanghai, China, Oral Presentation.
  11. Anu. P. Sebastian and Keerthi. T. R. (2011).“Probiotic potential of Bacillus subtilis isolated from
    milk and its antagonism against enteric pathogens”. World Congress on Biotechnology, Hyderabad,
    March 21-23, 2011 Oral Presentation.
  12. Aparna Balakrishna and Keerthi T. R. (2011).“Screening of potential aquatic probiotic from major
    microflora of Guppy”. Asian Congress on Biotechnology, “ACB 2011” held during May 11-15,
    Shanghai, China,Poster Presentation.
  13. Aparna Balakrishna and Keerthi. T. R. (2011).“Characterization of siderophore produced by the
    gut microflora of Poecilia reticulate for potential use as probiotic in aquaculture”. World Congress on
    Biotechnology, Hyderabad, March 21-23, 2011, Poster Presentation.
  14. Anu P. Sebastian and Keerthi T. R. (2010). “Study on Probiotic effect of Bacillus spore former and
    its effect on selected pathogens”. International Conference on Biotechnology for better life,
    November 15-16, 2010. Department of Biotechnology, Kalashlingam University, Tamil Nadu. Poster
    presentation.
  15. Jacob Anjali Ann, R. J. Praseeja and T. R. Keerthi. (2009).“Evaluation of Probiotic potential of
    Lactic acid bacteria isolated from Infant feces and the study of its effect on the Enteric Fever
    pathogens Salmonella typhi and Salmonella paratyphi A”. International Conference on challenges in
    Biotechnology and Food Technology, “ICBF-2009”, held at Annamalai University during 8- 10
    October, 2009.Oral Presentation.
  16. S. Rajeev Kumar, A. Sabu, M. Chandrasekharan, Keerthi T. R. (2001). “L- glutaminase production
    by immobilized Pseudomonas sp.”. BTMS 51. International conference on “New horizons in
    Biotechnology. Thiruvananthapuram. April 18- 21. 2001. Poster presentation.
  17. P.V. Suresh, A. Sabu, S. Rajeev Kumar, M. Chandrasekharan, Keerthi T. R. (2001). “Continous
    L- glutaminase production by Ca- alginate immobilized Beauveria sp. in a packed bed reactor”.
    International conference on “New horizons in Biotechnology” at Thiruvananthapuram.April 18-21.
    2001. Poster presentation.

National
Oral/Poster Presentations

  1. Anjali Ann jacob,Mathews Varkey &Keerthi.T.R(2016).Oral presentation “Agarase producing
    organisms from rhizoplane-A plant microbe interaction.National seminar on Plant Science
    Technology for Sustainable World organized by National Institute of Plant Science Technology
  2. Glindya Bhagya Lakshmi &Keerthi.T.R(2015).Oral presentation & Best paper award entitled
    “Probiotic based functional feed formulation by solid state fermentation using wheat bran”.Food
    safety in India-Current Issues and Career Prospects National Biotechnology Seminar 2015 held at
    Department of Biotechnology St.Peter’s college Kolenchery,Ernakulam,Kerala-682311.
  3. K. A. Athira Krishnan, T.R. Keerthi, and K. Jayachandran(2014) Screening of bioactivity and
    analysis of chemical constituents of two organic extracts of the marine sponge, Zygomycale parishii
    National Symposium on Emerging Trends in Biotechnology 2014: Department of
    Biotechnology,Cochin University of Science and Technology,Cochin. January 22-23, 2014.Oral
    presentation
  4. Nithin T. U., Keerthi T.R.,and LinuMathew(2014) Bioprospecting of novel marine bacteria
    Idiomarinaceae MBTU MB2 isolated from coastal region of Thrissur district National Symposium on
    Emerging Trends in Biotechnology 2014: Department of Biotechnology,Cochin University of Science
    and Technology,Cochin. January 22-23, 2014. Oral presentation
  5. Anu P. Sebastian and Keerthi T. R. (2012). “Adhesion and cell surface properties of wild species of
    Bacillus spore formers against enteric pathogens”. National Seminar on Life Style and Diseases.
    January 19-20, 2012. School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala. Oral
    presentation.
  6. T.R.Keerthi,Aparna Balakrishna and Sarigha Jayadevan (2012).”Bio control activity of different
    cellular components of four potential aquaculture probiotics against selected known fish pathogens.
    Oral presentation
  7. Anjali Anne Jacob, Sherin Joy Parapilly and Keerthi T. R. (2011).“In vitro probiotic
    characterization of Lactic Acid Bacteria isolated from infant feces with anti microbial action towards
    enteric fever pathogens”. National Seminar on Emerging Trends in Biopharmaceuticals, 26-27 August
    2011, St. Mary’s College, Trissur. Oral Presentation.
  8. Savitha K. Koilery and Keerthi T. R. (2011). “Biodiversity of marine yeast at different depth ranges
    in the coastal region of Arabian sea of Indian Peninsula”. National Symposium on Emerging Trends
    in Biotechnology held during September 1-2, 2011 at Cochin University of Science and Technology,
    Cochin. Poster Presentation.
  9. Anu P. Sebastian andKeerthi T. R. (2011).“Adhesion property is an enhanced probiotic potential of
    Bacillus subtilis MBTU_PBBM1 against Enteric pathogens”. National Seminar on Emerging Trends
    in Biopharmaceuticals, 26-27 August 2011, St. Mary’s College, Trissur.Oral Presentation.
  10. Savitha K. Koilery and Keerthi T. R. (2010).“Production of exopolysaccharides and cellbound
    polysaccharides from marine yeasts”. 1st Kerala Women’s Science Congress, 2010, held at St.
    Teresa’s College, Ernakulam from 10-12 August, 2010.Oral Presentation.
  11. Anu P. Sebastian and Keerthi T. R. (2010). “Study on Probiotic effect of wild species of Bacillus
    spores and its effect on enteric pathogens”. 1st Kerala Women’s Science Congress, 10-12 August 2010
    at St, Teresa’s College, Ernakulum. Oral Presentation.
  12. Aparna Balakrishna and Keerthi T. R. (2010). “Selection of potential aquatic probiotics from
    normal microflora of Guppy”. 1st Kerala Women’s Science Congress, 10-12 August 2010 at St,
    Teresa’s College, Ernakulum. Oral Presentation.
  13. Keerthi. T. R., P. V. Suresh, A. Sabu, S. Rajeev Kumar, M. Chandrasekharan.
    (1998).“Antineoplastic activity of L- glutaminase production by marine Pseudomonas sp.”.Diamond
    jubilee Symposia and 39th annual Conference of the Association of Microbiologists of India.
    Mangalore. December 5-7, 1998. Poster Presentation.
  14. P. V. Suresh, A. Sabu, S. Rajeev Kumar, M. Chandrasekharan andKeerthi T. R. (1998).“Lglutaminase
    production by an alkalophilic marine fungus – Beauveria sp.”. Diamond jubilee
    Symposia and 39th annual Conference of the Association of Microbiologists of India, Mangalore.
    December 5-7, 1998.Poster Presentation.7th Kerala Science Congress, Alappuzha. January 27-24, 2015. Poster
    Presentation

State

  1. Bincy Jacob, K.A. Athira Krishnan, T.R. Keerthi, K.Jaychandaran(2015). Antagonistic and
    cytotoxic effect of different cellular components of a marine symbiont MBTU-SOB1 from a marine
    sponge, Spongia officinalis var. ceylonensis 27th Kerala Science Congress, Alappuzha. January 27-24,
    2015. Poster Presentation.
  2. Sumayya Jauhara, Honey Chandran C., Keerthi T.R. (2015). Comparative evaluation of probiotic
    potency of Bacillus coagulans, MBTU-P1F2 from infant faeces with a kniwn probiotic Bacillus
    clausii from Enterogermina. 27th Kerala Science Congress, Alappuzha. January 27-24, 2015. Poster
    Presentation
  3. K.A. Athira Krishnan, T.R. Keerthi, and K. Jayachandran(2014) Bioactivity and chemical
    composition of two organic extracts prepared from Marine sponge, Spongia officinalis var.
    ceylonensis. 26th Kerala Science Congress 28-31, January, 2014, Wayanad, Kerala. Oral presentation
  4. Nithin T.U., T.R. Keerthi, and Linu Mathew (2014) Bioactive properties of ethyl acetate fraction of
    marine bacteria Staphylococcus warneri Proceedings of 26th Kerala Science Congress 28-31, January,
    2014, Wayanad, Kerala. Oral presentation.

Book Chapters

  1. Book entitled “Biosafety in India-Current Issues”, Publishers-Sooryagadha Publishers,ernakulam,
    ISBN978-81-7255-071-5
    a. Chapter entitled “Role of Probiotics in Functional food/ Neutraceuticals”. Keerthi.T.R:10-29
    b. Chapter entitled “Probiotic based Functional feed Formulation by Solid State Fermentation Using
    Wheat Bran”. Glyindya Bhagya Lakshmi & Keerthi.T.R:41-55
  2. Book entitled Enzymes in Food & Beverage processing Publishers: CRC publishers,Taylor and
    Francis Group.
    Chapter entitled “Enzymes in development of probiotics” Keerthi.T.R,Honey Chandran.C &
    Muthusamy Chandrasekaran.pp447-466.

Pharmaceutical nanotechnology Elsevier, 2016 ( Submitted).

  1. Hydrophobic and hydrophilic polymeric nanoparticles.
    Keerthi.T.R*.,Radhakrishnan.E.K.,Athira Krishnan.K.&Shiji Mathew
    School of Biosciences,Mahatma Gandhi University,Kottayam,Kerala,India
  2. Metal oxide nanoparticles
    Radhakrishnan.E.K1*, Keerthi.T.R1 and Shiji Mathew&Athira Krishnan.K
    1School of Biosciences,Mahatma Gandhi University,Kottayam,Kerala,India

Gen Bank Accession: Received Ten gene accession number from NCBI

Meyerozymaguilliermondii(JN128648),MBTU_PB1Enterobactersburiae(JN247801),MBTU_PB2Sta
phylococcussaprophiticus(JN247802),MBTU_PB3,Staphylococcussaprophyticus (JN247800),
MBTU_PB4Acenetobacter calcoaceticus(JN247799, MBTU PBBM1 Bacillus subtilis (JN873913),
Enterococuus faecium MBTU-P1F1-Rec G gene-KF745071, Enterococuus faecium MBTU-P1F116s
rRNA gene-KF745072.KT734853.,KT734854.

Seminars and workshops conducted/ organized

  1. CHIRPERSON-National seminar on “MISSION 3A –Awareness Against Antibiotic
    Resistance conducted at School of Biosciences , M.G.University, Kottayam from 16th-17 th
    November 2017.
  2.  CHIRPERSON-National seminar on “Ecotechnological Perspective for Sustainable
    Development conducted at School of Biosciences , M.G.University, Kottayam from 27-28 th
    July 2017 2017
  3. CHAIRPERSON- National seminar “ Recent trends in Applied Life Sciences( NSALS) conducted
    at School of Biosciences , M.G.University, Kottayam from 15 -16 th March 2017
  4. CHAIRPERSON – National workshop on “Advanced Statistical Tools & Softwares for Biological
    Research(ASSB)” organized with School of Biosciences,Mahatma Gandhi
    University,Kottayam,Kerala on 27th September to 1st October 2016.
  5. CHAIRPERSON –Institutional level two day seminar on “Prevention & management of lifestyle
    diseases” jointly organized with School of Biosciences & Department of student services (DSS) of
    M.G.University on 17 th & 18th March,2016.
  6. ORGANIZER- Seminar on “Cyber Space & Social Responsibility” jointly organized with School of
    Biosciences & PTA School of Biosciences on 28th December 2015
  7. ORGANIZER- Seminar on “Social responsibility in animal birth control” jointly organized with
    School of Biosciences &Indian Veterinary Association-Kerala in connection with World Spay Day
    on18th February 2016
  8. CO-CONVENOR State level seminar on “Stem Cell Therapy and Cancer” jointly organized by post
    graduate department of biotechnology SAS SNDP YOGAM College Konni and School of
    Biosciences M.G University on 14th February 2014.
  9. MEMBER, EXECUTIVE COMMITTEE State level workshop on “Molecular Phylogenetics in
    Microbiology” organized by School of Biosciences, M.G. University on 26th and 28th September
    2012.
  10. ORGANIZING SECRETORY National Seminar on “Life Style and Diseases” Organized by School
    of Biosciences, M.G. University. on January 19th and 20th 2012.

Workshop and trainings undergone

  1. Training cum workshop on molecular docking and drug designing 23-25 March 2015 organized
    by school of Biosciences ,Mahatma Gandhi University and BioDiscovery Group Life Sciences
  2. 2011 February 14-27-NAIP (ICAR-New Delhi) Sponsored training programme on“Molecular
    Diagnostics and Fingerprinting of Salmonella and pathogenic Vibrios associated with seafood
    and aquatic environment”. Organized by MFB division of CIFT, Cochin. Kerala.
  3. Training on Microbial Gene Manipulation (03-05-2010 t0 17-05-2-10) at Centre for Plant
    Biotechnology and Molecular Biology, College of Horticulture, Kerala Agricultural University.
  4. University workshop on Research Projects held on 02-04-2010 at the Mahatma Gandhi University
    Campus, Priyadarsini Hills, Kottayam.
  5. UGC Sponsored workshop on “Capacity building of Women Managers in Higher Education”
    held on 17-21 February 2009 at CMS College, Kottayam.

Membership in Scientific Societies

  • International Probiotics Association (IPA), Zurich, Switzerland
  • Asian Federation of Biotechnology (AFOB), Korea
  • Indian Dairy Association (IDA), New Delhi
  • Societyfor Biotechnology (India)
  • Association of Microbiologist in India (AMI), India .
  • Kerala Science Academy.

Reviewer

  • Iranian Journal of Biotechnology
  • 3Biotech
  • Brazilian Journal of Microbiology

Countries Visited for Scientific Purposes

  • China-2011
  • South Korea & Singapore-2012
  • Thailand-2013
  • Dubai-2014.
  • Switzerland-2017

ADMINISTRATIVE AND OTHER RESPONSIBILITIES

  1. Director, School of Biosciences,Mahatma Gandhi University ,17-08-2015 onwards
  2. Member Academic Council-Mahatma Gandhi University
  3. Chairperson,PhD Doctoral Committee of Biosciences
  4. Governing Body Member(University nomonee)St Albert Autonomous college,Ernakulam
  5. Co-Ordinator-DST –PURSE( PII),Mahatma Gandhi University(2016-2020)
  6. Co-Ordinator DST-FIST(L-I),School Of Biosciences,Mahatma Gandhi University.
  7. Chairperson, Institutional Animal Ethical Committee, Mahatma Gandhi University
  8. Convenor,Expert committee of M.Sc.Biotechnology,Mahatma Gandhi University
  9. Member, Board of Studies, (Biosciences), Mahatma Gandhi University.
  10. Member, Board of studies Microbiology (PG) Mahatma Gandhi University
  11. Member Board of Studies, Microbiology (PG&UG ), Kannur University(Former & Present).
  12. Member Board of Studies Microbiology(PG & UG),Calicut University.
  13. Subject Expert Women back to lab programme KSCSTE Thiruvanathapuram.
  14. Member Permenant cell to combact sexual harrasment Mahatma Gandhi University
  15. Member,(former Anti harrasment Cell Mahatma Gandhi University.
  16. Member (Former & Present) SC/ST monitoring cell of Mahatma Gandhi University
  17. Member Institutional Biosafety Committee, Mahatma Gandhi University
  18. Former Convener expert committee of B.Sc., Biotechnology, Mahatma Gandhi University
  19. Former Warden, Ladies Hostel, Mahatma Gandhi University.
  20. Member, Board of question paper setters and examiner in Biotechnology, Kannur University.
  21. Member, Board of question paper setters and examiner in Biotechnology and Microbiology
    (B.Sc.,M.Sc and MPhil), Calicut University.
  22. Member, Board of question paper setters in Biotechnology(M.Sc&B.Sc) Kerala
    University.
  23. P.T.A Secretary ,School of Biosciences-2013- 2015 batch
  24. Departmental Co-coordinator UGC remedial coaching -2013- 2015.

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